Daina wiwi: jadawalin ɗaukewar hazo
Alamun barin wiwi suna farawa cikin awa 24–48, suna kai ƙololuwa kusan rana ta 3, kuma galibi suna kwantawa cikin makonni 1–2 — yayin da barci da mafarkai masu ƙarfi na dawowar REM ke ɗaukar har wata guda. THC yana fita a hankali (yana narkewa a kitse): shan kullum mai yawa na iya bayyana a gwaji har makonni 4–12.
THC yana fita a hankali — yana narkewa a kitse, don haka ana auna fitarsa da makonni, ba awoyi ba. Wannan jinkirin shi ya sa alamun barin wiwi ke jin sauƙi amma na tsawon lokaci: fushi, barci mara natsuwa, da mafarkai masu ban mamaki na dawowar REM idan zagayen mafarkinka ya dawo aiki.
Wannan jadawali yana bin mako na farko na fushi, dawowar mafarki, komawar sha'awar abinci daidai, da hasken wata na biyu da yawancin masu dainawa ke kira 'ɗaukewar hazo'.
Alamun barin jaraba a taƙaice
| Alama | Farawa | Ƙololuwa | Sauƙi |
|---|---|---|---|
| Fushi | Awa 24–48 | Rana ta 3 | Makonni 1–2 |
| Wahalar barci da mafarki mai ƙarfi | Dare 2–3 | Mako na 1 | Makonni 2–6 |
| Faɗuwar sha'awar abinci | Rana 1–2 | Mako na 1 | Kwana 10–20 |
| Sha'awa | Rana ta 1 | Mako na 1 | Makonni 2–3 |
Kwatanta dukkan jadawalin barin jaraba 11 →
Jadawalin warkewar jikinka
Duhu
Girgizar Mai Karɓar CB1 · Kwanaki 0–3
Raguwar THC da Yunwar Cannabinoid Sa'o'i 0–24
Ana yanke ƙarfafawar THC mai tsanani, kuma masu karɓar CB1 na yin haza; asarar ci da ɓarnar circadian na farawa.
- Sa'a 2THC na Sauka daga Jini
Matakan THC a jini na fara sauka da sauri. Tasirin psychoactive na saukowa, ana maye da ɗan rashin natsuwa (agitation) da wahalar mai da hankali.
Ingantacciyar shaida - Sa'a 4An Yanke Ƙarfafawar CB1
Manne THC na waje da masu karɓar CB1 (cannabinoid-1) a kwakwalwa na tsayawa. Endocannabinoids na halitta na jikinka (anandamide da 2-AG) ba za su iya ƙarfafa waɗannan masu karɓar da suka yi haza tukuna ba.
Ingantacciyar shaida - Sa'a 6Rashin Natsuwa Mai Tsanani
Rashin ƙarfafa masu karɓar CB1 a amygdala da axis na damuwa na tunzura tsarin sympathetic. Rhythm na zuciya na ɗan hanzarta, kuma tashin hankali na ciki na farawa.
Ingantacciyar shaida - Sa'a 12Asarar Ci (Ghrelin)
Tasirin THC na ƙirƙirar sha'awar ci (munchies) ta ƙarfafa cibiyar ci a hypothalamus na ƙarewa. Ana danne sakin ghrelin (hormone na yunwa), kuma tashin zuciya da asarar ci na farawa.
Ingantacciyar shaida - Sa'a 18Ɓarnar Circadian
Tasirin kwantar da hankali (sedative) na THC kafin barci na ɓacewa. Zagayowar sakin melatonin na jikinka da daidaita zafi na ɓaci, kuma lokacin da ake ɗauka kafin barci na tsawaita sosai.
Ingantacciyar shaida - Sa'a 24Masu Karɓar CB1 na Farkawa
Da suka ji rashin THC, neurons na aika sakonni na kwayoyin don sake kunna masu karɓar CB1 marasa aiki a bangon selunansu da ƙara lambarsu (upregulation).
Ingantacciyar shaida
Dawowar REM da Zufar Dare Sa'o'i 24–78
Barcin REM da aka danne na dawowa da ƙarfi, zufar dare da sha'awa na kai ƙwanƙoli; sannan rikici mai tsanani na karyewa.
- Sa'a 30Mafarkai Masu Tsanani na Farawa (REM)
Danne matakin barci na REM (mafarki) na THC na ɗauke. Don rama lokacin mafarkin da aka hana shi tsawon lokaci, kwakwalwa na fara zagayowar mafarki mai tsanani, mai rikici, mai kama da gaske sosai.
Ingantacciyar shaida - Sa'a 36Zufar Dare
Rashin ƙarfafa masu karɓar CB1 a hypothalamus na sa zafin jiki ya hauhawa kwatsam da dare sannan ya sauka da zufa mai yawa.
Ingantacciyar shaida - Sa'a 42Ji na Motsin Rai
Sakin hormone na damuwa cortisol daga gland ɗin adrenal na zama marar tsari. Kana iya bayar da martani mai fushi sosai, mai ji, ko na motsin rai ga ƙaramar tunzura.
Shaida mai ma'ana - Sa'a 48Farkawar Mai Karɓa na Farawa
Da an yanke ƙarfafawar THC, kwakwalwa na fara tsarin ƙara jin da lambar masu karɓar CB1. Wannan upregulation na ɗaukar kwanaki zuwa makonni.
Shaida mai ma'ana - Sa'a 54Canjin Narkarwa
Rashin ƙarfafa masu karɓar cannabinoid a bangon hanji na hanzarta ko rage motsin hanji (peristalsis). Ƙwarƙwatar ciki da ciwon iskar gas na iya faruwa.
Shaida mai ma'ana - Sa'a 60Ƙwanƙolin Sha'awa
Tare da saurin da THC ke barin jiki, neman cannabis na hankali da jiki na kai ƙwanƙoli. Kwakwalwa na ƙarfafa striatum da neman-lada.
Ingantacciyar shaida - Sa'a 66Rashin Natsuwar Motsi
Canjin ji na masu karɓar cannabinoid a basal ganglia na haifar da ɗan rawa a hannu da jin rashin natsuwa na jiki.
Nuni kawai - Sa'a 72Rikici Mai Tsanani ya Karye
Matsin ilimin lissafin jiki na cirewar jiki mai tsanani (zufa, rawa, bugun zuciya) na fara saukowa daga ƙwanƙolinsa.
Ingantacciyar shaida - Sa'a 78Farkawar Anandamide
Maimakon THC na wucin gadi, kwakwalwa na ƙara samar da kwayar jin daɗinta na halitta, Anandamide (daga kalmar Sanskrit ta "farin ciki").
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Tsarkakewa
Tsaftace Sel · Kwanaki 3–21
Tsaftace Sel da Fashewar REM Kwanaki 4–21
Huhu na fitar da tar, THC na narkewa daga naman kitse, mafarkai na zama kamar sinima, kuma yawan CB1 na dawowa galibi.
- Rana 4Huhu na Tsaftacewa
Cilia da hayaƙi ya shanye a hanyoyin iska na fara motsin tsaftacewarsu. Ana tari tar da majina da suka taru a huhu.
Ingantacciyar shaida - Rana 5Mafarkai Kamar Sinima (Dawowar REM)
Barcin REM (mafarki) da THC ta danne na dawowa da ƙarfi (dawowar REM). A wannan matakin rama, kwakwalwa na sarrafa tunanin motsin rai; mafarkai masu haske, masu tsanani na yau da kullum ne.
Ingantacciyar shaida - Rana 6THC na Narkewa daga Kitse
THC yana da lipophilic sosai (mai narkewa cikin kitse). Kwayoyin THC da aka adana a selunan kitse na sakewa a hankali da ɗorewa cikin jini kuma na shiga tsarin fitarwa ta ƙodoji da bahaya.
Ingantacciyar shaida - Mako 1Ci na Halitta ya Dawo
Sakonnin ci a hypothalamus na fara aiki ba tare da dogaro ga ƙarfafawar THC ba. Ƙamshi da ɗanɗanon abinci na farkar da yunwa ta sinadaranka na halitta.
Ingantacciyar shaida - Rana 8Damuwa na Sauka
Yayin da yawan masu karɓar cannabinoid a amygdala ke ƙaruwa, tsoro, fahimtar barazana, da jin harin firgita marar ma'ana na fara ja da baya.
Ingantacciyar shaida - Rana 9Koyo na Farfaɗowa
Danne sakin acetylcholine a hippocampus na THC na ɗauke. Tsawon mai da hankali, saurin samun sabon bayani, da sassaucin hankali na ƙaruwa.
Ingantacciyar shaida - Rana 10Zufar Dare ta Ƙare
Cibiyar daidaita zafi ta hypothalamus na daidaita. Canje-canjen zafin jiki lokacin barcin dare na saukowa.
Ingantacciyar shaida - Rana 12Hazon Kwakwalwa ya Tsabtace
Daidaiton ƙarfafawa na prefrontal cortex na kafuwa. Saurin samun kalmomin da suka dace lokacin magana (santsin baki) da aikin ƙwaƙwalwar aiki na ɗan gajeren lokaci na ƙaruwa.
Ingantacciyar shaida - Rana 13Motsin Rai na Farkawa
Rashin ji na motsin rai (maganin sa barci na motsin rai) da THC ya ƙirƙira na ɗauke. Godiya ga hulɗar tsarin serotonin da oxytocin, tattaunawa da mutane na ba da jin daɗi na gaske.
Nuni kawai - Mako 2An Ƙarfafa Ƙwaƙwalwa (LTP)
Ƙarfin long-term potentiation (LTP - hanyar rikodin ƙwaƙwalwa) na synapses a neurons na hippocampus na 'yantu daga danniyar THC. Ƙwaƙwalwa na ƙarfafa.
Ingantacciyar shaida - Rana 15Numfashi ya Buɗe (HRV)
Kumburi mai ɗorewa a hanyoyin iska na ja da baya. Adadin oxygen da ke shiga alveoli na huhu na hauhawa, kuma matsin tsarin sympathetic a zuciya na raguwa.
Shaida mai ma'ana - Rana 16Daidaiton Jijiya (GABA/Glutamate)
Daidaito tsakanin manyan neurotransmitters na kwantar da hankali (GABA) da ƙarfafawa (Glutamate) na kwakwalwa na 'yantu daga jiyar THC kuma na kai homeostasis mafi kyau.
Shaida mai ma'ana - Rana 17Hanta ta Huce
Tsarin enzyme na cytochrome P450 na hanta (musamman CYP2C9 da CYP3A4) da suka yi aiki fiye da kima don narkar da THC na komawa saurinsu na tushe.
Ingantacciyar shaida - Rana 19Tsofaffin Jin Daɗi na Farkawa
Neurons na dopamine a striatum na daidaitawa da rayuwar halitta mara THC. Karanta littafi, kammala jin daɗi, ko motsa jiki na ba da jin daɗi mai tsabta.
Ingantacciyar shaida - Mako 3Masu Karɓar CB1 na Murmurewa
Binciken hoton PET (misali, Hirvonen et al.) na nuna cewa cikin makonni na tsaftacewa, yawan masu karɓar CB1 na murmurewa sosai zuwa matakin lafiya; cikakken daidaitawa na bambanta daga mutum zuwa mutum.
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