Daina kafein: sake saitin da tsarin jijiyoyinka ke yi
Alamun barin kafein suna farawa awa 12–24 bayan kason ƙarshe, suna kai ƙololuwa a awa 20–51, sannan su ƙare cikin kwanaki 2–9. Ciwon kai ita ce babbar alamar; rage kashi 10–25% kowace 'yan kwanaki yana taƙaita lanƙwasar gaba ɗaya sosai.
Kafein ba ya haifar da kuzari; yana toshe siginar gajiya ne. Ka daina, sai 'matsin barci' da ya taru ya dawo cikin 'yan kwanaki — shahararren ciwon kai na barin kafein kenan. Sannan masu karɓar adenosine ɗinka su koma daidai, kuma tsarin kuzarinka na kanka ya dawo aiki.
Jadawalin da ke ƙasa yana bin wannan sake saitin awa bayan awa: yaushe ciwon kai ke kai ƙololuwa, yaushe barci ke yin zurfi, yaushe nauyin safiya ke ɓacewa, da yaushe kuzarinka na yau da kullum ya daina dogara ga wani sinadari.
Alamun barin jaraba a taƙaice
| Alama | Farawa | Ƙololuwa | Sauƙi |
|---|---|---|---|
| Ciwon kai | Awa 12–24 | Awa 20–51 | Kwanaki 2–9 |
| Gajiya da nauyin barci | Awa 12–24 | Rana 1–2 | Makonni 1–2 |
| Faɗuwar yanayi da hazo | Rana ta 1 | Rana ta 2 | ~Mako 1 |
| Nauyin jiki kamar mura | Rana ta 1 | Rana ta 2 | Rana 2–4 |
Kwatanta dukkan jadawalin barin jaraba 11 →
Jadawalin warkewar jikinka
Duhu
Cirewa mai Tsanani · Kwanaki 0–3
Ɓarkewar Masu Karɓa Sa'o'i 0–24
An 'yanta masu karɓar adenosine, jijiyoyin kwakwalwa na faɗaɗa, kuma ciwon kai na farawa.
- Sa'a 5Matakin Caffeine ya Ragu Rabi
Caffeine da ke jininka na kaiwa rabin rayuwarsa. Enzyme CYP1A2 na hanta na ci gaba da narkar da caffeine, kuma ƙarfafawa a ƙananan jijiyoyin hannu da ƙafafunka na sauƙi.
Ingantacciyar shaida - Sa'a 6Manne Adenosine na Farawa
Kwayoyin caffeine na fara kwance daga masu karɓar adenosine A1. Adenosine na halitta na manne da masu karɓa da aka 'yanta, yana tunzura igiyar farko ta gajiya.
Ingantacciyar shaida - Sa'a 12Jijiyoyin Kwakwalwa na Faɗaɗa
Tasirin ƙuntata jijiyoyi (vasoconstrictor) na caffeine na ɓacewa gaba ɗaya. Jijiyoyin kwakwalwa na fara faɗaɗa. Sakonnin farko na ciwon kai na zuwa.
Ingantacciyar shaida - Sa'a 15Ƙarfafawar Dopamine na Sauka
Ji na dopamine da caffeine ke haifar da shi a striatum na tsayawa. Ƙarfafawar dopamine na sauka zuwa daidai, kuma ɗan asarar himma da ɗan fushi na faruwa.
Shaida mai ma'ana - Sa'a 18Adrenaline da Cortisol na Sauka
Ƙarfafa gland ɗin adrenal na tsayawa. Matakan epinephrine da cortisol na plasma na sauka. Hawan jini na tsari na ɗan sauƙi.
Ingantacciyar shaida - Sa'a 24Ƙwanƙolin Ciwon Kai
Gudanar jini zuwa kwakwalwa (gudanar jini na kwakwalwa) na kai matakinsa mafi girma. Jijiyoyi da suka faɗaɗa fiye da kima na matsawa ƙarshen jijiyar trigeminal da ke kewaye, suna haifar da ciwon kai mai bugawa.
Ingantacciyar shaida
Hazon Kwakwalwa da Ciwon Tsoka Sa'o'i 24–78
Hazon kwakwalwa da ciwon tsoka na kai ƙwanƙoli, sannan bugawa mai tsanani na karyewa.
- Sa'a 30Bugun Zuciya ya Ragu
Bugun zuciyarka na raguwa da bugu 3–7 a minti. Yayin da tasirin caffeine mai ɗorewa na hanzarta zuciya ke ɗauke, tsarin jijiya na kai na ja zuciya zuwa saurin hutunta.
Ingantacciyar shaida - Sa'a 36Taurin Tsoka da Ciwo
Tasirin caffeine na ɗaga ƙarfin tsoka ta hanyar ƙarfafa neurons na motsi na ɓacewa. Tauri da ciwo kamar tarin lactic acid na farawa a tsokokin kafaɗa, wuya, da baya.
Shaida mai ma'ana - Sa'a 42Narkar da Abinci ya Ragu
Caffeine na daina ƙarfafa masu karɓar acetylcholine a santsin tsokar hanji. Motsin hanji na raguwa, kuma ɗan halin kumburi da maƙarƙashiya na farawa.
Ingantacciyar shaida - Sa'a 48Ƙwanƙolin Hazon Kwakwalwa
Duk biliyoyin ƙarin masu karɓar adenosine a kwakwalwa yanzu sun cika da adenosine. Saurin sako tsakanin sel na jijiya na raguwa na ɗan lokaci.
Ingantacciyar shaida - Sa'a 54Ramuwar Barci
Jikinka na tsawaita barci don biyan bashin barci mai ɗorewa na caffeine. Barcin rana na kai ƙwanƙoli.
Ingantacciyar shaida - Sa'a 60Canjin Cortisol
Axis na hypothalamus-pituitary na ƙoƙarin daidaitawa da al'ada mara caffeine. Lokacin sakin cortisol na ɓata, yana haifar da saurin fushi da rashin haƙuri.
Shaida mai ma'ana - Sa'a 66Daidaita Sukarin Jini
Tasirin caffeine na tunzura sakin glucose daga hanta ta hanyar adrenaline na ɓacewa. Canjin sukarin jini na fara kwantawa.
Shaida mai ma'ana - Sa'a 72Bugawa na Karyewa
Jijiyoyin kwakwalwa na daidaitawa da sabon girma da hawan jini da suka faɗaɗa. Matsin trigeminal a bangon jijiya na ƙarewa, kuma ciwon kai mai bugawa na sauƙi.
Ingantacciyar shaida - Sa'a 78Tsaftace Masu Karɓa na Farawa
Kwakwalwa na lura da rashin ƙarfafawa. Na fara sakonni cikin sel don kashe (downregulate) ƙarin masu karɓar adenosine.
Shaida mai ma'ana
Tsarkakewa
Tsaftace Sel · Kwanaki 3–21
Gyaran Nama Kwanaki 4–21
Ƙarin masu karɓar gajiya na kashewa, barci da gland ɗin adrenal na hutawa, kuma gyaran nama na farawa.
- Rana 4Jijiyoyin Kwakwalwa na Daidaita
Jijiyoyin kwakwalwa da suka faɗaɗa na kwantawa a girman daidai mai lafiya. Ciwon kai daga faɗaɗar jijiyoyi na wucewa galibi.
Ingantacciyar shaida - Rana 5Rhythm na Hanji na Halitta
Santsin tsokokin hanji na fara aiki bisa rhythm na tsarin jijiyar hanjinsu (peristalsis), ba tare da ƙarfafawar sinadari na caffeine ba.
Ingantacciyar shaida - Rana 6Gland ɗin Adrenal na Hutawa
An 'yanta gland ɗin adrenal daga gajiyar caffeine mai ɗorewa. Samar da adrenaline (epinephrine) na halitta na sake daidaitawa, kuma jin ƙonewa na sauƙi.
Shaida mai ma'ana - Rana 7Barci Mai Zurfi na Dawowa
Ana sake saita ɓarnar caffeine ga tsarin barci. Matakin barci mai gyara jiki, mai sakin hormone na girma (matakan NREM 3 da 4) na tsawaita.
Ingantacciyar shaida - Rana 8Sake Ba da Ruwa ga Sel
Tasirin caffeine na fitar da fitsari a nephrons na ƙoda na ƙarewa. Daidaiton riƙe ruwa da sodium na jikinka na maidowa, kuma ruwa cikin sel na hauhawa.
Ingantacciyar shaida - Rana 9Masu Karɓar Gajiya na Raguwa
Ƙarin masu karɓar adenosine da caffeine ke ƙarfafa koyaushe a hankali na fara komawa lambarsu ta daidai da ƙarfafawa ta tsaya. Gajiyar safiya mai nauyi na fara sauƙi.
Shaida mai ma'ana - Rana 10Ƙarfin Safiya na Halitta
Jikinka na koyon ɗaga lanƙwasar cortisol nata ta halitta a lokacin farkawa ba tare da caffeine ba (martanin farkawa na komawa daidai).
Shaida mai ma'ana - Rana 11Nauyin Zuciya ya Sauƙi
Ƙarfafa catecholamine mai ɗorewa na tsokar zuciya na ɗauke. Nauyin aikin ventricle na hagu na sauka, kuma tashin hankali na tsokar zuciya na hutu na sauka.
Ingantacciyar shaida - Rana 12Ƙarfin Tsoka ya Daidaita
Tashin hankali mai ɗorewa a tsokokinka na ƙarewa. Ciwon tashin hankali daga cirewar caffeine a tsokokin kwarkwata, kafaɗa, da wuyanka na ɓacewa galibi.
Shaida mai ma'ana - Rana 13Tacewar Ƙoda cikin Daidaito
Matsin ƙananan jijiyoyi a glomeruli na ƙoda na daidaita. Saurin ƙodoji na tace fitsari da riƙe electrolytes na kai matakin lafiya.
Ingantacciyar shaida - Rana 14An Maido da Reflexes
Da sake daidaita masu karɓa, saurin isar da sako tsakanin sel na jijiya (axonal transport) na komawa daidai. Lokacin martanin hankali na taƙaita.
Shaida mai ma'ana - Rana 16Fata na Samun Danshi
Da sake ba da ruwa ga ƙananan jijiyoyin ƙarƙashin fata, samar da sebum na daidaita. Fata mai bushewa da ɓawo da caffeine ya haifar na ɓacewa.
Shaida mai ma'ana - Rana 18Matsin Cikin Ido ya Daidaita
Tasirin caffeine na ɗaga tashin ido (matsin cikin ido) na ɓacewa. Ƙananan jijiyoyin ido na huce kuma bushewar ido na sauƙi.
Ingantacciyar shaida - Rana 20Ƙarfi Mai Ɗorewa Tsawon Rana
Da sukarin jini da adrenaline sun daidaita, faɗuwar ƙarfi kwatsam a rana da faɗuwar caffeine na ƙarewa.
Shaida mai ma'ana - Rana 21'Yancin Jijiya
Masu karɓar adenosine da caffeine ya ninka na komawa lambarsu ta daidai cikin makonni bayan ƙarfafawa ta tsaya (downregulation). Dogaro na jiki na ƙarewa galibi.
Ingantacciyar shaida